Soriatane
Soriatane is a systemic retinoid primarily used for the treatment of severe psoriasis and other disorders of keratinization. As a form of acitretin, it works to normalize the growth and differentiation of skin cells, thereby reducing the thick, scaly plaques characteristic of psoriatic lesions. Its unique mechanism offers a viable option for patients whose conditions have not responded adequately to topical therapies or phototherapy.
The mechanism of action of Soriatane involves modulating gene expression through its interaction with retinoic acid receptors in the skin. By binding to these receptors, acitretin helps regulate the growth and differentiation of keratinocytes, the predominant cell type in the epidermis. This action not only slows down the rapid turnover of skin cells seen in psoriasis but also helps reduce inflammation, leading to an overall improvement in the appearance and texture of the skin.
Clinically, Soriatane is indicated for patients with severe psoriasis, including those with pustular or erythrodermic variants, who have not responded to other treatments. It is often considered when the benefits of treatment outweigh the potential risks associated with systemic retinoid therapy. Soriatane may be used as monotherapy or in combination with other modalities such as phototherapy, depending on the individual patient's condition and response to treatment.
Dosing of Soriatane is carefully tailored to the patient, typically based on body weight and the severity of the disease. It is administered orally, often with meals to improve absorption and reduce gastrointestinal discomfort. Because of its potent systemic effects, patients undergoing treatment with Soriatane require regular monitoring, including liver function tests and lipid profiles, to detect any adverse effects early and adjust the dosage as necessary.
Despite its efficacy, Soriatane is associated with a range of side effects. Common adverse effects include dry skin, cheilitis (inflammation of the lips), and elevated liver enzymes. One of the most significant concerns is its high teratogenic potential, meaning it can cause severe birth defects if taken during pregnancy. As a result, strict contraception measures are mandated for women of childbearing potential before, during, and after treatment, and the drug is contraindicated in pregnancy.
Overall, Soriatane provides a valuable treatment option for patients with severe, recalcitrant psoriasis by addressing the underlying abnormalities in skin cell turnover and inflammation. Its use requires careful patient selection, education, and ongoing monitoring to balance its therapeutic benefits against its potential risks. When managed appropriately under the guidance of a healthcare professional, Soriatane can significantly improve quality of life for patients battling difficult-to-treat skin conditions.
NOTE: The above information is for marketing purposes only and is not to be construed as medical advice. Seek advice for medications from a qualified physician.
The mechanism of action of Soriatane involves modulating gene expression through its interaction with retinoic acid receptors in the skin. By binding to these receptors, acitretin helps regulate the growth and differentiation of keratinocytes, the predominant cell type in the epidermis. This action not only slows down the rapid turnover of skin cells seen in psoriasis but also helps reduce inflammation, leading to an overall improvement in the appearance and texture of the skin.
Clinically, Soriatane is indicated for patients with severe psoriasis, including those with pustular or erythrodermic variants, who have not responded to other treatments. It is often considered when the benefits of treatment outweigh the potential risks associated with systemic retinoid therapy. Soriatane may be used as monotherapy or in combination with other modalities such as phototherapy, depending on the individual patient's condition and response to treatment.
Dosing of Soriatane is carefully tailored to the patient, typically based on body weight and the severity of the disease. It is administered orally, often with meals to improve absorption and reduce gastrointestinal discomfort. Because of its potent systemic effects, patients undergoing treatment with Soriatane require regular monitoring, including liver function tests and lipid profiles, to detect any adverse effects early and adjust the dosage as necessary.
Despite its efficacy, Soriatane is associated with a range of side effects. Common adverse effects include dry skin, cheilitis (inflammation of the lips), and elevated liver enzymes. One of the most significant concerns is its high teratogenic potential, meaning it can cause severe birth defects if taken during pregnancy. As a result, strict contraception measures are mandated for women of childbearing potential before, during, and after treatment, and the drug is contraindicated in pregnancy.
Overall, Soriatane provides a valuable treatment option for patients with severe, recalcitrant psoriasis by addressing the underlying abnormalities in skin cell turnover and inflammation. Its use requires careful patient selection, education, and ongoing monitoring to balance its therapeutic benefits against its potential risks. When managed appropriately under the guidance of a healthcare professional, Soriatane can significantly improve quality of life for patients battling difficult-to-treat skin conditions.
NOTE: The above information is for marketing purposes only and is not to be construed as medical advice. Seek advice for medications from a qualified physician.
Soriatane
Acitretin
Generic: ACTOID
Acitretin
Generic: ACTOID
25mg
20 CAP
20 CAP
$62.40